/
Questions/
Assignment/
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for: Medicinal Chemistry Assignment, UniS, UK
Looking For Plagiarism Free Answers For Your UK College/ University Assignments.
BUY NOWYou are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for: Medicinal Chemistry Assignment, UniS, UK
University | University Of Surrey (UniS) |
---|---|
Subject | Medicinal Chemistry |
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for. Your team has already found a compound that can moderate the activity of the kinase of interest.
- Using this information, use AutoDockTools and Autodock Vina to dock your compound with the kinase of interest. Your report should include
- A brief explanation of how you determine the search area for the docking, accompanied by a suitable picture to show where the search box is located with respect to the kinase in your docking.
You can click “Ligand Interaction” which will bring you to a new page displaying where and how a drug molecule interacts with the kinase. You can use your mouse to rotate and zoom in/out to help you visualize the binding site.
Once you have a good understanding of where the binding site should be, you need to adjust the dimensions, scaling factor, and the center of the search box in AutoDockTools based on this information. You need to make sure you define the search box correctly in your conf.txt file. - Description of possible interactions between your compound and the kinase that you have identified after docking, accompanied by a suitable picture and labeling to highlight the interactions.
- A table to show the binding affinity of your compound and the kinase from docking.
- Based on the results from the molecular docking, and also using your knowledge of medicinal chemistry, make FIVE changes you would make to the molecule in order to probe SAR and increase binding efficiency. Your answer should be a maximum of ONE A4 page in length, should concisely describe why you are making those changes, and should include chemical drawings of your hit compound and subsequent analogs in order to visualize those changes.
Buy Answer of This Assessment & Raise Your Grades
Get help by expert
Experience worry-free academic support at the University of Surrey (UniS) in the UK. Our specialized Homework Writing Help and dependable Assignment Writing Service UK are tailored to your needs. Whether it’s Medicinal Chemistry or any subject, our experts are here for you. With a focus on your pharmaceutical industry assignment involving kinase inhibitor development, success awaits with our dedicated assistance. Join satisfied students who’ve elevated their studies with us.
Recent solved questions
- ILM: Assess own leadership behaviours and potential in the context of a particular leadership model and own organisation's working practices and culture: Leadership skills and development, Assignment, UOA, UK
- ILM: Describe the factors that will influence the choice of leadership styles or behaviours in workplace situations: Leadership skills and development, Assignment, UOA, UK
- ATHE Level 7 Unit 5 : You Have Been A Senior Manager For Several Years And Have Decided That Your Next Career Move Should Be To Take Responsibility: Personal Development for Leadership and Strategic Management Assignment, UK
- You are required to prepare a 5-year strategy review to shareholders for evaluating the business simulation: 5-year strategy review to shareholders, Report, UOEL, UK
- CMI Unit 502: Approaches to achieving a balance of skills and experience in a team: Principles of Developing, Managing and Leading Individuals and Teams, Assignment, UK
- CMI Unit 502: Principles of Developing, Managing and Leading Individuals and Teams, Assignment, UK
- UNIT-701: How the principles of strategic leadership can be applied to respond to complex organisational challenges: Strategic Leadership, Assignment, CMI, UK
- UNIT- 701: The leadership behaviours and skills required to deliver strategic goals: Strategic Leadership, Assignment, CMI, UK
- UNIT- 701: Understanding of how the organisational context influences management and leadership practice: Strategic Leadership, Assignment, CMI, UK
- Evaluate the concept of evidence-based practice and assess how approaches to evidence-based practice: Evidence - based practices, Report, UOH, UK